DRUG METABOLISM AND DRUG INTERACTIONS

VOLUME. 14, NO. 2, 1997

CONTENTS

Clinical Implications of Genetic Polymorphisms and Drug Interactions Mediated by Cytochrome P-450 Enzymes

D.J. Touw, The Netherlands ........ 55

Microsomal Metabolism of N-Benzyl-N-Ethylaniline and N-Benzyl-N-Ethyl-p-Toluidine

Mert Ulgen, Ufuk Ozer, Ilkay Kucukguzel and John W. Gorrod, Turkey and UK .......... 83

Preventive Effect of Isoflurane on Destruction of Cytochrome P-450 During Reductive Dehalogenation of Carbon Tetrachloride in Guinea-pig Liver Microsomes

Kohyu Fujii, Japan ............ 99

The Inhibitory Effects of the Fluoroquinolone Antimicrobials Norfloxacin and Enrofloxacin on Hepatic Microsomal Cytochrome P-450 Monooxygenases in Broiler Chickens

A. Shlosberg, E. Ershov, M. Bellaiche, V. Hanji, Y. Weisman and S. Soback, Israel ................ 109

© Freund Publishing House Ltd. 1997