DRUG METABOLISM AND DRUG INTERACTIONS

VOLUME 15, NO. 1, 1999

CONTENTS

Cytochrome P450 Substrate Specificities, Substrate Structural Templates and Enzyme Active Site Geometries

D.F.V. Lewis, M. Dickins, P.J. Eddershaw, M.H. Tarbit and P.S. Goldfarb, UK ...........1

Pharmacokinetic and Pharmacodynamic Interactions between Dehydroepiandrosterone and Prednisolone in the Rat

G.M.L. Meno-Tetang, Y. Yi Hon, S.Van Wart and W.J. Jusko, USA ...........51

Time Dependent Influence of Diazepam on the Pharmacokinetics of Ibuprofen in Man

A. Thukaram Bapuji, D. Rambhau, P. Srinivasu, B. Ramesh Rao and S.S. Apte, India ..........71

Dose Independent Pharmacokinetics of Caffeine after Intravenous Administration under a Chronic Food-limited Regimen

C. Smith, F. Ma and C.E. Lau, USA .........83

© Freund Publishing House Ltd. 1999