DRUG METABOLISM AND
DRUG INTERACTIONS

VOLUME 16, NO. 2, 2000

CONTENTS

Investigation of Phenobarbital-Carbamazepine-Valproic Acid Interactions using Population Pharmacokinetic Analysis for Optimisation of Antiepileptic Drug Therapy: An Overview

E. Yukawa, Japan ..........85

Interaction Energy Analyses of Folate Analog Binding to Human Dihydrofolate Reductase: Contribution of the Antifolate Substructural Regions to Complex Stability

C. Pitts, D. Bowen and W.M. Southerland, USA ........99

Effect of Black Tea on Lipid Peroxidation in Carbon Tetrachloride Treated Male Rats

D. Sür-Altıner and B. Yenice, Turkey ........123

The Contributions of Various Chloroquine Salts to the Biliary and Urinary Execretion of Hepatic Paracetamol Conjugation Metabolites in the Rat

E. Oforah and S. Anyogo, Nigeria .........129

Can Absolute Oral Bioavailability in Humans be Predicted from Animals? A Comparison of Allometry and Different Indirect Methods

I. Mahmood, USA ........143

Book Reviews ...........157

© Freund Publishing House Ltd. 2000