Drug Metabolism and Drug Interactions

DRUG METABOLISM AND
DRUG INTERACTIONS

VOLUME 18, NO. 3-4, 2001

CONTENTS

Ginger: An Ethnomedical, Chemical and Pharmacological Review

M. Afzal, D. Al-Hadidi, M. Menon, J. Pesek and M.S.I. Dhami, Kuwait, USA and Pakistan .........159

Effects of Encapsulation of Primidone on its Oxidative Metabolism in Rats

V. Ferranti, C. Chabenat, H. Marchais, S. Ménager, H. Hue, A.M. Orecchioni and O. Lafont, France ..........191

Interaction of Fluoroquinolones and Certain Ionophores in Broilers: Effect on Blood Levels and Hepatic Cytochrome P450 Monooxygenase Activity

E. Ershov, M. Bellaiche, V. Hanji, S. Soback, M. Gips and A. Shlosberg, Israel .........209

Quantitative Structure-Activity Relationships (QSARs) Within Substrates of Human Cytochromes P450 Involved in Drug Metabolism

D.F.V. Lewis, S. Modi and M. Dickins, UK ............221

Isoflurane Aggravates the Decrease of Phosphatidycholine Synthesis in Alveolar Type II Cells Induced by Hydrogen Peroxide

T. Yang, Y. Li, Q. Liu, J. Tao, W. Wu and H. Huang, China .........243

Effect of Administration Route and Length of Exposure on Pharmacokinetics and Metabolism of Diltiazem in Dogs

P.K.F. Yeung, J.D.Z. Feng, and S.J. Buckley, USA ..........251

Lack of CYP3A4 Inhibition by Grapefruit Juice and Ketoconazole upon Clozapine Administration in Vivo

H.-Y. Lane, C.C. Chiu, Y. Kazmi, H. Desai, Y.W.F. Lam, M.W. Jann and W.-H. Chang, Taiwan and USA ..........263

Book Reviews .........279

Index ............283