DRUG METABOLISM AND
DRUG INTERACTIONS

VOLUME 19, NO. 1, 2002

CONTENTS

Pharmacokinetics of Fluvoxamine in Relation to CYP2C19 Phenotype and Genotype

M.W. Jann, T.L. ZumBrunnen, Y.R. Kazmi, C.M. VanDenBerg, H.D. Desai, D.J. Weidler and D.A. Flockhart, USA ..........1

Decreased Hepatic Drug Metabolising Enzyme Activity in Rats with Nitrosamine-induced Tumours

P.P. Maliakal, P.F. Coville and S. Wanwimolruk, New Zealand and USA ............13

Molecular Orbital Calculations and Nicotine Metabolism: A Rationale for Experimentally Observed Metabolite Ratios

D.F.V. Lewis and J.W. Gorrod, UK ..............29

Effect of Cephalexin on the Pharmacokinetics of Metformin in Healthy Human Volunteers

G. Jayasagar, M. Krishna Kumar, K. Chandrasekhar, C. Madhusudan Rao and Y. Madhusudan Rao, India ...........41

Prediction of Clearance in Humans from In Vitro Human Liver Microsomes and Allometric Scaling. A Comparative Study of the Two Approaches

I. Mahmood, USA ...........49

Book Reviews ...........65

© Freund Publishing House Ltd. 2002