Drug Metabolism and Drug Interactions

DRUG METABOLISM AND
DRUG INTERACTIONS

VOLUME 20, NO. 1-2, 2004

CONTENTS

The Effect of Cysteine Analogues on the Excretion of Urinary Sulphate in the Rat Following Cysteine Administration

E.S. Roopnarinsingh, G.B. Steventon, R.M. Harris, R.H. Waring and S.C. Mitchell, UK ...........1

Intravenous Pharmacokinetics and Metabolism of the Reactive Oxygen Scavenger a-Phenyl-N-Tert-Butyl Nitrone (PBN) in the Cynomolgus Monkey

M.E. Lame, A.S. Kalgutkar and M. LaFontaine, USA .........11

Effect of Gemfibrozil on the Metabolism of Pitavastatin - Determining the Best Animal Model for Human CYP And UGT Activities

H. Fujino, T. Saito, Y. Tsunenari and J. Kojima, Japan ..........25

Effects of Chinese, Japanese and Western Tea on Hepatic P450 Enzyme Activities in Rats

N. Niwattisaiwong, X.-X. Luo, P.F. Coville and S. Wanwimolruk, Thailand, China, New Zealand and USA ............43

Metabolism of CDRI-85/92, a New Potent Anti-ulcer Agent, Involving Cis-Trans Conversion

P. Srivastava, P. Sharma, J. Lal, D.K. Dikshit, K.P. Madhusudanan and R.C. Gupta, India ...........57

Impact of Truncated Area Under the Curve on Failed Bioequivalence Studies: A Computer Simulation Analysis

I. Mahmood, USA ...........77

Estimation of Absorption Rate Constant (k_a) Following Oral Administration by Wagner-Nelson, Loo-Riegelman, and Statistical Moments in the Presence of a Secondary Peak

I. Mahmood, USA ...........85

SHORT COMMUNICATION

In Vitro Susceptibility of Candida Species Isolated from Cancer Patients to Some Antifungal Agents

B. Özçelik, S. Çıtak, S. Cesur, U. Abbasoğlu and F. Içli, Turkey ........101

Book Review ..........109