DRUG METABOLISM AND DRUG INTERACTIONS

VOLUME 21, NO. 3-4, 2006

CONTENTS

The Influence of P-Glycoprotein on Cerebral and Hepatic Concentrations of Nortriptyline and its Metabolites

T.B. Ejsing, J. Hasselstrøm and K. Linnet, Denmark .............. 139

Drug-Drug Interactions of Anti-Infective Drugs: Utility of Fluorescence CYP Inhibition Assays in Drug Discovery

M. Fridén, K. Vanaja and V.N. Nandi, India ........... 163

In Vitro Studies on Quetiapine Metabolism Using the Substrate Depletion Approach with Focus on Drug-Drug Interactions

J. Hasselstrøm and K. Linnet, Denmark ............. 187

Quantitative Structure-Activity Relationships (QSARs) Within Cytochromes P450 2B (CYP2B) Subfamily Enzymes: The Importance of Lipophilicity for Binding and Metabolism

D.F.V. Lewis, B.G. Lake, Y. Ito and P. Anzenbacher, UK, Japan and Czech Republic ........... 213

Variations in Content of Active Ingredients Causing Drug Interactions in Grapefruit Juice Products Sold in California

S. Wanwimolruk and P.V. Marquez, USA ............. 233

Comparative Proteomics Analysis of Differentially Expressed Phosphoproteins in Adult Rat Ventricular Myocytes Subjected to Diazoxide Preconditioning

H. Li, Y.-b. Xiao, Y.-Q. Gao and T.-d. Yang, China .............. 245

Index .............. 259