JOURNAL OF

PEDIATRIC ENDOCRINOLOGY & METABOLISM

VOLUME 11, NUMBER 3, MAY-JUNE 1998

TABLE OF CONTENTS

REVIEW

Childhood Diabetes Towards the 21st Century

Z. Laron, Tel Aviv, Israel ............ 387

ORIGINAL COMMUNICATIONS

Effect of Long-Term Recombinant Growth Hormone Therapy in Children - The National Cooperative Growth Study, USA, 1985-1994

A.W. Root, S.F. Kemp, A.C. Rundle, K. Dana and K.M. Attie, on Behalf of the National Cooperative Growth Study, USA ......... 403

Decreased Lumbar Spine Bone Mass and Low Bone Turnover in Children and Adolescents with Insulin Dependent Diabetes Mellitus Followed Longitudinally

P. Gunczler, R. Lanes, V. Paz-Martinez, R. Martinis, S. Esaa, V. Colmenares and J.R. Weisinger, Caracas, Venezuela ........... 413

Puberty and Mineralization of the Skeleton in Girls

Z. Orbak, H. Yildirim and N. Zor, Erzurum, Turkey ........... 421

The Effects of Pubertal Status and Glycemic Control on the Growth Hormone-IGF-I Axis in Boys with Insulin-Dependent Diabetes Mellitus

P.A. Clark, W.L. Clarke, S. Pedadda, A. Reiss, C. Langlois, F. Nieves-Rivera and A.D. Rogol, VI, USA .......... 427

Urinary Free Cortisol and its Nyctohemeral Variation in Adolescents and Young Adults with IDDM: Relation to Endothelin 1 and Indices of Diabetic Angiopathy

C. Dacou-Voutetakis, M. Peppa-Patrikiou and M. Dracopoulou, Athens, Greece ........... 437

Incidence of Insulin Dependent Diabetes Mellitus in Children 0-14 Years Old in the Veneto Region, Italy

L. Pinelli, F. Beretta, P. Dalla Bernardina, E. Gonfiantini and P. Groff, Verona, Italy .......... 447

Insulin-like Growth Factor Axis Parameters in Sick Hospitalized Neonates

A. Bhala, M.C. Harris, S. Zirin, L. Corcoran and P. Cohen, Philadelphia, PA, USA ........... 451

SHORT COMMUNICATIONS

Lack of Seasonality in the Month of Onset of Childhood IDDM (0.7-15 years ) in Shanghai, China

J. Ye, R.-G. Chen, I. Ashkenazi and Z. Laron, Shanghai, China and Tel Aviv, Israel ........ 461

Detection of Gly-196-Ser Mutation in 5a-Reductase Type II Gene in a Brazilian Patient with Female Assignment and Behavior

L.F. Caldas Ferraz, G. Guerra Jr., M.T. Matias Baptista, A.T. Maciel-Guerra and C. Hackel, São Paulo, Brazil ........... 465

PATIENT REPORTS

A Young Boy with a Thyroid Yo-Yo

D. Gillis, R. Volpe and D. Daneman, Jerusalem, Israel and Toronto, Canada ........ 467

Increased Urinary Excretion of Pyridinoline and Deoxypyridinoline in a Girl with Congenital Contractural Arachnodactyly

Y. Fujisawa, K. Yamashita, Y. Nakamura and K. Kida, Ehime, Japan ...... 471

Forum and Correspondence ........ 475

Book Reviews ............ 477

Calendar ............... 481