JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM

VOLUME 11, SUPPLEMENT 1, MARCH, 1998

ISPAD WORKSHOP ON HYPOGLYCEMIA

Stockholm, Sweden, June 1997

Guest Editors: Z. Laron (Israel) and G. Bolli (Italy)

CONTENTS

Foreword ...... 97

Carbohydrates as a Cerebral Metabolic Fuel

M. Evans and S.A. Amiel, UK ........... 99

Counterregulatory Mechanisms to Insulin-Induced Hypoglycemia in Humans: Relevance to the Problem of Intensive Treatment of IDDM

Geremia B. Bolli, Italy ........... 103

Hypoglycemia Due to Hormone Deficiencies

Zvi Laron, Israel .......... 117

Ions and Genes in Persistent Hyperinsulinaemic Hypoglycaemia in Infancy: A Commentary on the Implications for Tailoring Treatment to Disease Pathogenesis

A. Aynsley-Green, M.J. Dunne, R.F.L. James and K.J. Lindley, UK ........... 121

Persistent Hyperinsulinemic Hypoglycemia of Infancy: Long Term Results

C. Dacou-Voutetakis, F. Psychou and M. Maniati-Christidis, Greece .......... 131

Preoperative Use of Octreotide in a Newborn with Persistent Hyperinsulinemic Hypoglycemia of Infancy

R. Anıl Apak, Murat Yurdakök, Alcay Oran, M. Emin Şenocak and Melda Çağlar, Turkey ............143

Hypoglycemia in Childhood: A Clinical Approach

A. Verrotti, P. Fusilli, R. Pallotta, G. Morgese and F. Chiarelli, Italy ............ 147

Hypoglycemia During Intensified Insulin Therapy of Young Children

Carine E. de Beaufort, Luxembourg .......... 153

Hypoglycaemia During Intensified Insulin Therapy of Children and Adolescents

Johnny Ludvigsson and Sam Nordfeldt, Sweden ........... 159

Problems of Hypoglycemia Arising in Children and Adolescents with Insulin-Dependent Diabetes Mellitus

F. Dammacco, C. Torelli, E. Frezza, E. Piccinno, F. Tansella and the Diabetes Study Group of the Italian Society of Pediatric Endocrinology & Diabetes, Italy ........... 167

Hypoglycemia in Children with Diabetes: Incidence, Counterregulation and Cognitive Dysfunction

E.A. Davis and T.W. Jones, Australia ........... 177

High Incidence of Hypoglycemic Episodes with Neurologic Manifestations in Children with Insulin Dependent Diabetes Mellitus

N. Shehadeh, J. Kassem, I. Tchaban, S. Ravid, E. Shahar, T. Naveh and A. Etzioni, Israel ........... 183

Maternal Fear of Hypoglycemia in their Children with Insulin Dependent Diabetes Mellitus

William L. Clarke, Linda A. Gonder-Frederick, Andrea L. Snyder and Daniel J. Cox, USA .......... 189