JOURNAL OF

PEDIATRIC ENDOCRINOLOGY & METABOLISM

VOLUME 12, NUMBER 1, JANUARY-FEBRUARY 1999

TABLE OF CONTENTS

Letter from the Editors ............ 1

REVIEWS

Pancreas Transplantation

Z. Shapira, A. Yussim and E. Mor, Tel Aviv, Israel ............ 3

Endocrine Dysfunction in Children with HIV-1 Infection

F. Chiarelli, A. Verrotti, L. Galli, F. Basciani and M. de Martino, Chieti and Florence, Italy ........... 17

ORIGINAL CONTRIBUTIONS

The Prevalence of Mitochondrial Gene Mutations in Childhood Diabetes in Japan

N. Matsuura, S. Suzuki, Y. Yokota, K. Kazahari, M. Kazahari, T. Toyota, M. Hirai, A. Okuno, S. Harada, N. Fukushima, A. Koike, Y. Ito and T. Hotsubo, Sagamihara, Sendai, Asahikawa, Sapporo, Tonan and Hokkaido, Japan ........... 27

Quality of Paediatric IDDM Care in Germany: A Multicentre Analysis

W. Hecker, M. Grabert and R.W. Holl for the German Paediatric Diabetology Group, Stuttgart and Ulm, Germany .......... 31

Human Insulin Induces a Higher Glucagon Response to Induced Hypoglycemia in Short Normal Children, Compared to Porcine Insulin

C. Kanaka-Gantenbein, C. Catzeflis, U. Keller, M. Fathi, G.E. Theintz and P.C. Sizonenko, Geneva, Basel and Lausanne, Switzerland ............ 39

GH Response to Exercise: Assessment of the Pituitary Refractory Period, and Relationship with Circulating Components of the GH-IGF-I Axis in Adolescent Females

A. Eliakim, J.A. Brasel and D.M. Cooper, Torrance and Irvine, CA, USA ........... 47

Effects of a Low Dose of Melatonin on Sleep in Children with Angelman Syndrome

I.V. Zhdanova, R.J. Wurtman and J. Wagstaff, Cambridge and Boston, MA, USA ......... 57

Thyroid Function Tests in the Newborn Infants of Preeclamptic Women

N. Narin, S. Kurtoğlu, M. Başbuğ, H. Çaksen, M. Kafalı, A.C. Durak, E. Genç and F. Narin, Kayseri, Turkey ............ 69

Short-term Changes in Lower Leg Length in Children Treated for Acute Lymphoblastic Leukaemia

S.F. Ahmed, W.H.B. Wallace, P.M. Crofton, B. Wardhaugh, R. Magowan and C.J.H. Kelnar, Edinburgh, UK ........ 75

SHORT COMMUNICATIONS

Ketoconazole Treatment of Gonadotropin Independent Precocious Puberty in Girls with McCune-Albright Syndrome: A Preliminary Report

F.A. Syed and S.A. Chalew, Baltimore, MD, USA .......... 81

Severe Hypoglycemia in Spanish Diabetic Children and Adolescents

M.J. López, M. Oyarzabal, M. Rodríguez, R. Barrio, F. Hermoso, L. Blasco and Study Group of Infantile Diabetes of the Spanish Paediatric Endocrinology Society, Valencia, Pamplona, Zaragoza, Madrid and Valencia, Spain ........... 85

PATIENT REPORTS

Fertility and its Complications in a Patient with Salt Losing Congenital Adrenal Hyperplasia

M. Zacharin, Parkville, Vic, Australia ........ 89

Localized Lipoatrophy due to Recombinant Growth Hormone Therapy in a Child with 6.7 Kilobase Gene Deletion Isolated Growth Hormone Deficiency

A. Büyükgebiz, A. Aydın, B. Dündar and K. Yörükoğlu, Izmir, Turkey .......... 95

Growth Hormone Isoforms in a Girl with Gigantism

L.L. Co Ng, F.I. Chasalow, O. Escobar and S.L. Blethen, Stony Brook, NY, San Carlos , CA and Brooklyn, NY, USA ......... 99

FORUM AND CORRESPONDENCE ......... 107

BOOK REVIEWS ......... 109

MEETINGS CALENDAR ......... 111