TABLE OF CONTENTS

33rd INTERNATIONAL SYMPOSIUM ON GROWTH HORMONE AND GROWTH FACTORS IN ENDOCRINOLOGY AND METABOLISM 

33rd International Symposium / 1st International Workshopon Genetics of Growth Disorders, Spain

Guest editors: A. Carrascosa, I.A. Hughes, B. Lippe, and R. Rapaport

Foreword ...  1217

Plenary Lecture

Ghrelin: Endocrine and Non-endocrine Actions

F. Broglio, E. Arvat, A. Benso, M. Papotti, G. Muccioli, R. Deghenghi and E. Ghigo, Italy and France ........  1219

Catch-Up Growth: Why, When, How?

Catch-Up Growth: Definition, Mechanisms, and Models

J.-M. Wit and B. Boersma, The Netherlands  ... 1229

Early Spontaneous Catch-Up Growth

J. Karlberg, K. Albertsson-Wikland, C.W. Kwan and F.Y.S. Chan, PR China and Sweden   ... 1243

Catch-Up Growth: New Lessons for the Clinician

M.B. Ranke, Germany ....  1257

Growth Without Growth Hormone

M. Phillip, O. Moran and L. Lazar, Israel  ... 1267

SGA: An Update on Management

A Growth Prediction Model for Short Children Born Small for Gestational Age 

M.B. Ranke, W.S. Cutfield, A. Lindberg, C.T. Cowell, K. Albertsson-Wikland, E.O. Reiter, P. Wilton, D.A. Price, on behalf of the KIGS International Board, Germany, New Zealand, Sweden, Australia, USA and UK .............  1273

Development of a Consensus Statement on Management of Short Children Born Small for Gestational Age

S.D. Chernausek, USA ............  1275

Effects of Long-Term GH Treatment on Insulin Sensitivity and Glucose Tolerance

A.C.S. Hokken-Koelega, T. Sas and Y. van Pareren, The Netherlands  ... 1277

Genetics, Genes and Growth

Imprinting Disorders: Non-Mendelian Mechanisms Affecting Growth

M.G. Butler, USA  ... 1279

SHOX Haploinsufficiency and its Modifying Factors

T. Ogata, Japan ...  1289

The Definition of the Y Chromosome Growth-Control Gene (GCY) Critical Region: Relevance of Terminal and Interstitial Deletions

S. Kirsch, B. Weiß, K. Schön and G.A. Rappold, Germany ....................  1295

New GH-1 Gene Mutations: Expanding the Spectrum of Causes of Isolated Growth Hormone Deficiency

P.E. Mullis, J. Deladoëy and P.S. Dannies, Switzerland and USA ............  1301

The Adrenal in the Third Millennium

Development and Function of the Human Fetal Adrenal Cortex

D. Langlois, J.Y. Li and J.M. Saez, France ........  1311

Advances in the Understanding of the Genetic Basis of Adrenal Insufficiency

H.L. Storr, M.O. Savage and A.J.L. Clark, UK ...  1323

Congenital Adrenal Hyperplasia: Phenotype and Genotype

I. Hughes, UK ......  1329

Effects of Glucocorticoids on the Skeleton

E. Canalis, R.C. Pereira and A.M. Delany, USA  ... 1341

Transition from Pediatric to Adult GHD Treatment: Metabolic and Endocrine Studies

Metabolic Effects of Stopping Growth Hormone: Body Composition and Energy Expenditure

J.W. Gregory, UK  ... 1347

Skeletal Consequences of Discontinuation of Growth Hormone at Final Height

W.M. Drake, P.V. Carroll, M.O. Savage and J.P. Monson, UK  ...  1351

Continuation of Growth Hormone Therapy Versus Placebo in Transition-Phase Patients with Growth Hormone Deficiency: Impact on Body Composition, Insulin Sensitivity, and Thyroid Function

J.O.L. Jørgensen, H. Nørrelund, N. Vahl, A. Juul, N.E. Skakkebæk and J.S. Christiansen, Denmark ....  1355

Transitioning Patients with Childhood-Onset Growth Hormone Deficiency to Treatment in Adulthood

R.G. Rosenfeld, USA ............  1361

Female Adolescent Endocrinology

Detection of Insulin Resistance and its Treatment in Adolescents with Polycystic Ovary Syndrome

R.S. Legro, USA ...  1367

Eating Disorders in Females: Genetics, Pathophysiology, and Treatment

K.A. Halmi, USA  ... 1379

Nature or Nurture: Determinants of Peak Bone Mass in Females

C.T. Cowell and C. Tao, Australia ......  1387

Selected Poster Abstracts

Growth Hormone I - Growth Hormone Treatment  ... 1397

Growth Hormone II - Pituitary, Physiology, GH Treatment  ... 1403

Growth, Steroids, Other Medical Conditions  ... 1407

Small for Gestational Age, Prader-Willi Syndrome, Turner’s Syndrome ...  1410

Genetic Syndromes and Systemic Diseases ....  1416

FIRST INTERNATIONAL WORKSHOP ON GENETICS OF GROWTH DISORDERS

Foreword ...  1421

Hypothalamic and Pituitary Defects

Structural Hypothalamic Defects

M. Dattani, UK ...  1423

Defects of Pituitary Development

S. Amselem, France .........  1425

Molecular Mechanisms Responsible for Combined Pituitary Hormone Deficiency

S. Radovick, USA . ...  1427

GH Receptor, GH Gene, SHOX

Human Growth Hormone I Gene Expression is Influenced in a Complex Haplotype-Dependent Fashion by Polymorphic Variation in Both the Proximal Promoter and the Locus Control Region

D.N. Cooper, M. Horan, D.S. Millar, J. Hedderich, G. Lewis, V. Newsway, N. Mo, L. Fryklund, A.M. Procter and M. Krawczak, UK   ...  1429

GHRH Receptor Defects

G. Baumann, USA  ... 1431

Mutations of the GH Gene

J.A. Phillips III, USA ............  1435

Syndromes of Growth Hormone Bioinactivity

K. Chihara, Japan  ... 1437

SHOX Defects in Idiopathic Short Stature

T. Ogata, Japan ...  1439

New Mutations

NESTEGG: Aims and Strategies

L.B. Johnston, L. Fryklund, A.J.L. Clark, A. Hokken-Koelega, M. Ranke, M.O. Savage and M. Tauber (the NESTEGG Steering Group), UK, Sweden, The Netherlands, Germany and France ........  1441

Physiology of Normal Growth Hormone Receptor Function

M.J. Waters and C.A. Shang, Australia ....  1443

Molecular Modeling of Growth Hormone Receptor Mutations

D.K. Smith, PR China .........  1447

Phenotypic Variability in Growth Hormone Insensitivity

M.O. Savage, J.C. Blair, C.P. Burren, C. Camacho-Hübner, K.A. Woods, L. Metherell and A.J.L. Clark, UK  ... 1449

GH Signaling, IGF-I Generation

Growth Hormone Signal Transduction and Possible Defects in Children

P.E. Clayton and C.M. Silva, UK and USA ............  1451

IGF Generation in Short Stature

C.K. Buckway, K.A. Selva, C.P. Burren, K.L. Pratt, E. Tjoeng, J. Guevara-Aguirre and R.G. Rosenfeld, USA, UK and Ecuador ...  1453

Molecular Physiology of IGF-I Expression

P. Rotwein, J. Billiard and J. Woelfle, USA  ... 1455

Gene Association Studies in Small for Gestational Age Infants

L.B. Johnston, N. Arends, J. Dahlgren, J. Leger, P. Czernichow, K. Albertsson-Wikland, C. van Duijn, A. Hokken-Koelega, M.O. Savage and A.J.L. Clark, UK, The Netherlands, Germany and France ........  1459

ISSN 0334-018X/15-S5

243 pages

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