REVIEWS IN THE NEUROSCIENCES

SPECIAL ISSUE: TRANSGENICS AND PSYCHOPHARMACOLOGY

Guest editors: C.A. Marsden and A. Rex

VOLUME 11, NO. 1, 2000

Transgenics and Psychopharmacology - Introduction

Charles A. Marsden and André Rex, UK and Germany .........1

Practical and Theoretical Issues in Gene-Targeting Studies and their Application to Behaviour

Jim J. Hagan, Alex J. Harper, Heather Elliott, Declan N.C. Jones and Derek C. Rogers, UK ........3

Targeting Genes and Proteins in the Analysis of Learning and Memory: Caveats and Future Directions

Robert Gerlai, USA ..........15

Transgenic Animal Models for Neuropharmacology

Michael Bader, Germany .........27

From Genotype to Phenotype - Behavior of the Transgenic Rat TGR(mREN2)27 as an Example

Jörg-Peter Voigt, André Rex, Michael Bader and Heidrun Fink, Germany .........37

Transgenic Approaches to Model Alzheimer’s Disease

Bernd Sommer, Christine Sturchler-Pierrat, Dorothee Abramowski, Karl-Heinz Wiederhold, Michael Calhoun, Mathias Jucker, Peter Kelly and Matthias Staufenbiel, Switzerland ........47

Animal Models of Depression: Utility for Transgenic Research

Roger D. Porsolt, France .........53

Measurement of Anxiety in Transgenic Mice

Scott M. Weiss, Sean Lightowler, Kelly J. Stanhope, Guy A. Kennett and Colin T. Dourish, UK .........59

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ISSN 0334-1763/11:1

74 pages

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